CJC-1295 NO DAC

This product is synthesized and distributed exclusively for in vitro laboratory experimentation and in vivo animal research models. It is strictly NOT intended for human consumption, diagnostic procedures, or therapeutic use. All handling, reconstitution, and deployment must be conducted by qualified laboratory professionals using proper personal protective equipment.

Overview

CJC-1295 No DAC, also known as Modified GRF (1-29) or Mod GRF (1-29), is a synthetic 29-amino acid analogue of growth hormone-releasing hormone (GHRH). It contains four amino acid substitutions that increase resistance to enzymatic degradation while retaining a short pharmacokinetic profile due to the absence of the Drug Affinity Complex (DAC). As a result, CJC-1295 No DAC is widely utilized as a research tool for investigating physiological growth hormone pulsatility, pituitary GHRH receptor signalling, and endocrine regulation.

Unlike CJC-1295 with DAC, the No DAC variant does not bind to serum albumin and exhibits a substantially shorter half-life, making it particularly valuable in experimental models designed to evaluate pulsatile hormone secretion and receptor-mediated endocrine signalling.

Key Research Applications

Growth Hormone-Releasing Hormone (GHRH) Receptor Pharmacology

Widely utilized to investigate activation of the GHRH receptor and the downstream intracellular signalling pathways involved in endogenous growth hormone secretion.

Endocrine Signalling

Studied in laboratory models to evaluate physiological regulation of the hypothalamic-pituitary-growth hormone (HPGH) axis, including receptor activation, feedback mechanisms, and pulsatile hormone release.

Growth Hormone Pulsatility

Applied in experimental studies examining the temporal dynamics of endogenous growth hormone secretion, providing a model for investigating physiological pulsatile endocrine signalling.

IGF-1 Axis Research

Investigated for its effects on growth hormone-mediated insulin-like growth factor-1 (IGF-1) signalling pathways in preclinical endocrine research.

Cellular Growth and Protein Metabolism

Utilized in laboratory investigations exploring cellular growth mechanisms, protein synthesis pathways, tissue metabolism, and anabolic signalling associated with growth hormone physiology.

Peptide Pharmacology

Frequently employed as a comparative research compound for evaluating pharmacokinetic and pharmacodynamic differences between short-acting GHRH analogues and long-acting DAC-modified peptides.

Technical Specifications

Classification: Growth Hormone-Releasing Hormone (GHRH) Analogue

Alternative Names: Modified GRF (1-29); Mod GRF (1-29)

Peptide Type: Synthetic 29-Amino Acid Peptide

Primary Target: Growth Hormone-Releasing Hormone Receptor (GHRHR)

Appearance: White to off-white lyophilized powder

Purity: ≥98% (HPLC)

Solubility: Water-soluble following appropriate laboratory reconstitution procedures

Scientific References & Literature Citations

Growth Hormone-Releasing Hormone Analogue Development

Teichman, S. L., Neale, A., Lawrence, B., et al. (2006). Prolonged Stimulation of Growth Hormone (GH) and Insulin-Like Growth Factor I Secretion by CJC-1295, a Long-Acting Analog of Growth Hormone-Releasing Hormone, in Healthy Adults. Journal of Clinical Endocrinology & Metabolism, 91(3), 799–805.

Official Article: https://academic.oup.com/jcem/article/91/3/799/2843374

PubMed: https://pubmed.ncbi.nlm.nih.gov/16352683/

Growth Hormone-Releasing Factor Analogue Structure

Coy, D. H., et al. (1987). Differential Effects of N-Terminal Modifications on the Biological Potencies of Growth Hormone-Releasing Factor Analogues. Peptides.

PubMed: https://pubmed.ncbi.nlm.nih.gov/3100799/

Growth Hormone-Releasing Factor Structure-Activity Relationships

Robberecht, P., Coy, D. H., et al. (1985). Structural Requirements for the Activation of Rat Anterior Pituitary Adenylate Cyclase by Growth Hormone-Releasing Factor. Endocrinology.

PubMed: https://pubmed.ncbi.nlm.nih.gov/2994998/

Growth Hormone Physiology

Veldhuis, J. D., et al. Studies investigating pulsatile growth hormone secretion and neuroendocrine regulation. Journal of Clinical Endocrinology & Metabolism.

Technical Documentation Notice

This material is supplied exclusively for laboratory research purposes. For validated technical information regarding growth hormone-releasing hormone analogues, pituitary GHRH receptor pharmacology, endocrine signalling pathways, and growth hormone physiology, researchers are encouraged to consult peer-reviewed scientific literature and established biomedical databases, including PubMed/NCBI, using the primary publications referenced above.

For Research Use Only (RUO). Not for human consumption, veterinary use, clinical application, or diagnostic procedures.