{"product_id":"retatrutide","title":"Retatrutide","description":"\u003cp\u003e\u003cstrong\u003eThis product is synthesized and distributed exclusively for in vitro laboratory experimentation and in vivo animal research models. It is strictly NOT intended for human consumption, diagnostic procedures, or therapeutic use. All handling, reconstitution, and deployment must be conducted by qualified laboratory professionals using proper personal protective equipment.\u003c\/strong\u003e\u003c\/p\u003e\n\u003ch2\u003eOverview\u003c\/h2\u003e\n\u003cp\u003eRetatrutide is a synthetic, long-acting peptide engineered as a \u003cstrong\u003etriple hormone receptor agonist\u003c\/strong\u003e, targeting the glucagon-like peptide-1 (GLP-1), glucose-dependent insulinotropic polypeptide (GIP), and glucagon receptors. This multi-receptor pharmacological profile has made Retatrutide an important investigational compound in metabolic research, enabling scientists to explore the combined physiological effects of incretin and glucagon signalling on energy homeostasis, glucose metabolism, adipose tissue biology, and hepatic function.\u003c\/p\u003e\n\u003cp\u003eIts extended duration of action and balanced receptor activity make it a valuable tool for studying complex metabolic pathways in both cellular and preclinical animal models.\u003c\/p\u003e\n\u003chr\u003e\n\u003ch2\u003eKey Research Applications\u003c\/h2\u003e\n\u003cp\u003e\u003cstrong\u003eTriple Receptor Pharmacology:\u003c\/strong\u003e\u003cbr\u003eWidely investigated for its simultaneous activation of GLP-1, GIP, and glucagon receptors to evaluate integrated endocrine signalling pathways involved in metabolic regulation.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eEnergy Homeostasis \u0026amp; Metabolic Regulation:\u003c\/strong\u003e\u003cbr\u003eUtilized in experimental models to examine mechanisms influencing energy expenditure, nutrient utilization, substrate oxidation, and whole-body metabolic adaptation.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eGlucose Metabolism:\u003c\/strong\u003e\u003cbr\u003eStudied in laboratory settings to investigate receptor-mediated effects on glucose homeostasis, insulin secretion, glucagon signalling, and glycaemic regulation in metabolic disease models.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eAdipose Tissue Biology:\u003c\/strong\u003e\u003cbr\u003eResearched for its influence on adipocyte function, lipid metabolism, fat storage dynamics, and cellular pathways involved in energy balance.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eHepatic Metabolism:\u003c\/strong\u003e\u003cbr\u003eApplied in experimental studies evaluating liver lipid metabolism, hepatic glucose production, and metabolic signalling associated with non-clinical models of metabolic dysfunction.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eCardiometabolic Research:\u003c\/strong\u003e\u003cbr\u003eInvestigated for its effects on biomarkers associated with cardiovascular and metabolic physiology in preclinical research, including inflammatory signalling, lipid metabolism, and vascular function.\u003c\/p\u003e\n\u003chr\u003e\n\u003ch2\u003eTechnical Specifications\u003c\/h2\u003e\n\u003cp\u003e\u003cstrong\u003eClassification:\u003c\/strong\u003e Triple GLP-1\/GIP\/Glucagon Receptor Agonist\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003ePeptide Type:\u003c\/strong\u003e Synthetic Long-Acting Peptide\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eReceptor Targets:\u003c\/strong\u003e GLP-1 Receptor (GLP-1R), GIP Receptor (GIPR), Glucagon Receptor (GCGR)\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eAppearance:\u003c\/strong\u003e White to off-white lyophilized powder\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003ePurity:\u003c\/strong\u003e ≥98% (HPLC)\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eSolubility:\u003c\/strong\u003e Water-soluble following appropriate laboratory reconstitution procedures\u003c\/p\u003e\n\u003chr\u003e\n\u003ch2\u003eScientific References \u0026amp; Literature Citations\u003c\/h2\u003e\n\u003ch3\u003eDiscovery \u0026amp; Pharmacology\u003c\/h3\u003e\n\u003cp\u003eJastreboff, A. M., et al. (2023). \u003cem\u003eTriple-Hormone-Receptor Agonist Retatrutide for Obesity – A Phase 2 Trial.\u003c\/em\u003e New England Journal of Medicine, 389, 514–526.\u003c\/p\u003e\n\u003cp\u003eCoskun, T., et al. (2022). \u003cem\u003eLY3437943, a Novel Triple GIP, GLP-1 and Glucagon Receptor Agonist for the Treatment of Obesity.\u003c\/em\u003e Cell Metabolism.\u003c\/p\u003e\n\u003ch3\u003eMetabolic Mechanisms\u003c\/h3\u003e\n\u003cp\u003eMüller, T. D., et al. (2018). \u003cem\u003eGlucagon Receptor Activation in the Regulation of Energy Balance and Body Weight.\u003c\/em\u003e Molecular Metabolism.\u003c\/p\u003e\n\u003ch3\u003eIncretin Biology\u003c\/h3\u003e\n\u003cp\u003eNauck, M. A., \u0026amp; Meier, J. J. (2019). \u003cem\u003eIncretin Hormones: Their Role in Health and Disease.\u003c\/em\u003e Diabetes, Obesity and Metabolism.\u003c\/p\u003e\n\u003cp\u003eCampbell, J. E., \u0026amp; Drucker, D. J. (2021). \u003cem\u003ePharmacology, Physiology and Mechanisms of Incretin Hormone Action.\u003c\/em\u003e Cell Metabolism.\u003c\/p\u003e\n\u003chr\u003e\n\u003ch2\u003eTechnical Documentation Notice\u003c\/h2\u003e\n\u003cp\u003eThis material is supplied exclusively for laboratory research purposes. For validated technical information regarding triple receptor agonists, incretin biology, glucagon receptor pharmacology, and metabolic signalling pathways, researchers are encouraged to consult peer-reviewed scientific literature and established biomedical indexing resources, including PubMed\/NCBI, using the primary research publications referenced above.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eFor Research Use Only (RUO). Not for human consumption, veterinary use, clinical application, or diagnostic procedures.\u003c\/strong\u003e\u003c\/p\u003e","brand":"Seren Labs | UK | Research Peptides","offers":[{"title":"Default Title","offer_id":57622123905406,"sku":null,"price":80.0,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1009\/0263\/3854\/files\/ChatGPTImageJun28_2026_09_19_06PM.png?v=1783431025","url":"https:\/\/www.seren-labs.com\/products\/retatrutide","provider":"Seren Labs | UK | Research Peptides","version":"1.0","type":"link"}