{"product_id":"cjc-1295-no-dac","title":"CJC-1295 NO DAC","description":"\u003cp data-start=\"0\" data-end=\"374\" class=\"PDq2pG_selectionAnchorContainer\"\u003e\u003cstrong data-start=\"0\" data-end=\"374\"\u003eThis product is synthesized and distributed exclusively for in vitro laboratory experimentation and in vivo animal research models. It is strictly NOT intended for human consumption, diagnostic procedures, or therapeutic use. All handling, reconstitution, and deployment must be conducted by qualified laboratory professionals using proper personal protective equipment.\u003c\/strong\u003e\u003cspan aria-hidden=\"true\" class=\"PDq2pG_selectionAnchor\"\u003e\u003c\/span\u003e\u003c\/p\u003e\n\u003ch2 data-section-id=\"rzkdgm\" data-start=\"376\" data-end=\"387\"\u003eOverview\u003c\/h2\u003e\n\u003cp data-start=\"389\" data-end=\"932\"\u003eCJC-1295 No DAC, also known as \u003cstrong data-start=\"420\" data-end=\"443\"\u003eModified GRF (1-29)\u003c\/strong\u003e or \u003cstrong data-start=\"447\" data-end=\"465\"\u003eMod GRF (1-29)\u003c\/strong\u003e, is a synthetic 29-amino acid analogue of growth hormone-releasing hormone (GHRH). It contains four amino acid substitutions that increase resistance to enzymatic degradation while retaining a short pharmacokinetic profile due to the absence of the Drug Affinity Complex (DAC). As a result, CJC-1295 No DAC is widely utilized as a research tool for investigating physiological growth hormone pulsatility, pituitary GHRH receptor signalling, and endocrine regulation.\u003c\/p\u003e\n\u003cp data-start=\"934\" data-end=\"1243\"\u003eUnlike CJC-1295 with DAC, the No DAC variant does not bind to serum albumin and exhibits a substantially shorter half-life, making it particularly valuable in experimental models designed to evaluate pulsatile hormone secretion and receptor-mediated endocrine signalling. \u003cspan class=\"\" data-state=\"closed\"\u003e\u003c\/span\u003e\u003c\/p\u003e\n\u003chr data-start=\"1245\" data-end=\"1248\"\u003e\n\u003ch2 data-section-id=\"6bvmjm\" data-start=\"1250\" data-end=\"1278\"\u003eKey Research Applications\u003c\/h2\u003e\n\u003ch3 data-section-id=\"v101h8\" data-start=\"1280\" data-end=\"1345\"\u003eGrowth Hormone-Releasing Hormone (GHRH) Receptor Pharmacology\u003c\/h3\u003e\n\u003cp data-start=\"1347\" data-end=\"1511\"\u003eWidely utilized to investigate activation of the GHRH receptor and the downstream intracellular signalling pathways involved in endogenous growth hormone secretion.\u003c\/p\u003e\n\u003ch3 data-section-id=\"1133iuf\" data-start=\"1513\" data-end=\"1537\"\u003eEndocrine Signalling\u003c\/h3\u003e\n\u003cp data-start=\"1539\" data-end=\"1745\"\u003eStudied in laboratory models to evaluate physiological regulation of the hypothalamic-pituitary-growth hormone (HPGH) axis, including receptor activation, feedback mechanisms, and pulsatile hormone release.\u003c\/p\u003e\n\u003ch3 data-section-id=\"kdxs11\" data-start=\"1747\" data-end=\"1777\"\u003eGrowth Hormone Pulsatility\u003c\/h3\u003e\n\u003cp data-start=\"1779\" data-end=\"1964\"\u003eApplied in experimental studies examining the temporal dynamics of endogenous growth hormone secretion, providing a model for investigating physiological pulsatile endocrine signalling.\u003c\/p\u003e\n\u003ch3 data-section-id=\"19iw894\" data-start=\"1966\" data-end=\"1989\"\u003eIGF-1 Axis Research\u003c\/h3\u003e\n\u003cp data-start=\"1991\" data-end=\"2138\"\u003eInvestigated for its effects on growth hormone-mediated insulin-like growth factor-1 (IGF-1) signalling pathways in preclinical endocrine research.\u003c\/p\u003e\n\u003ch3 data-section-id=\"fnmjj4\" data-start=\"2140\" data-end=\"2182\"\u003eCellular Growth and Protein Metabolism\u003c\/h3\u003e\n\u003cp data-start=\"2184\" data-end=\"2373\"\u003eUtilized in laboratory investigations exploring cellular growth mechanisms, protein synthesis pathways, tissue metabolism, and anabolic signalling associated with growth hormone physiology.\u003c\/p\u003e\n\u003ch3 data-section-id=\"bkhwi1\" data-start=\"2375\" data-end=\"2399\"\u003ePeptide Pharmacology\u003c\/h3\u003e\n\u003cp data-start=\"2401\" data-end=\"2593\"\u003eFrequently employed as a comparative research compound for evaluating pharmacokinetic and pharmacodynamic differences between short-acting GHRH analogues and long-acting DAC-modified peptides.\u003c\/p\u003e\n\u003chr data-start=\"2595\" data-end=\"2598\"\u003e\n\u003ch2 data-section-id=\"1cgu054\" data-start=\"2600\" data-end=\"2627\"\u003eTechnical Specifications\u003c\/h2\u003e\n\u003cp data-start=\"2629\" data-end=\"2697\"\u003e\u003cstrong data-start=\"2629\" data-end=\"2648\"\u003eClassification:\u003c\/strong\u003e Growth Hormone-Releasing Hormone (GHRH) Analogue\u003c\/p\u003e\n\u003cp data-start=\"2699\" data-end=\"2757\"\u003e\u003cstrong data-start=\"2699\" data-end=\"2721\"\u003eAlternative Names:\u003c\/strong\u003e Modified GRF (1-29); Mod GRF (1-29)\u003c\/p\u003e\n\u003cp data-start=\"2759\" data-end=\"2808\"\u003e\u003cstrong data-start=\"2759\" data-end=\"2776\"\u003ePeptide Type:\u003c\/strong\u003e Synthetic 29-Amino Acid Peptide\u003c\/p\u003e\n\u003cp data-start=\"2810\" data-end=\"2879\"\u003e\u003cstrong data-start=\"2810\" data-end=\"2829\"\u003ePrimary Target:\u003c\/strong\u003e Growth Hormone-Releasing Hormone Receptor (GHRHR)\u003c\/p\u003e\n\u003cp data-start=\"2881\" data-end=\"2934\"\u003e\u003cstrong data-start=\"2881\" data-end=\"2896\"\u003eAppearance:\u003c\/strong\u003e White to off-white lyophilized powder\u003c\/p\u003e\n\u003cp data-start=\"2936\" data-end=\"2959\"\u003e\u003cstrong data-start=\"2936\" data-end=\"2947\"\u003ePurity:\u003c\/strong\u003e ≥98% (HPLC)\u003c\/p\u003e\n\u003cp data-start=\"2961\" data-end=\"3049\"\u003e\u003cstrong data-start=\"2961\" data-end=\"2976\"\u003eSolubility:\u003c\/strong\u003e Water-soluble following appropriate laboratory reconstitution procedures\u003c\/p\u003e\n\u003chr data-start=\"3051\" data-end=\"3054\"\u003e\n\u003ch2 data-section-id=\"yn2eex\" data-start=\"3056\" data-end=\"3103\"\u003eScientific References \u0026amp; Literature Citations\u003c\/h2\u003e\n\u003ch3 data-section-id=\"cixwlb\" data-start=\"3105\" data-end=\"3162\"\u003eGrowth Hormone-Releasing Hormone Analogue Development\u003c\/h3\u003e\n\u003cp data-start=\"3164\" data-end=\"3472\"\u003e\u003cstrong data-start=\"3164\" data-end=\"3224\"\u003eTeichman, S. L., Neale, A., Lawrence, B., et al. (2006).\u003c\/strong\u003e \u003cem data-start=\"3225\" data-end=\"3404\"\u003eProlonged Stimulation of Growth Hormone (GH) and Insulin-Like Growth Factor I Secretion by CJC-1295, a Long-Acting Analog of Growth Hormone-Releasing Hormone, in Healthy Adults.\u003c\/em\u003e \u003cstrong data-start=\"3405\" data-end=\"3455\"\u003eJournal of Clinical Endocrinology \u0026amp; Metabolism\u003c\/strong\u003e, 91(3), 799–805.\u003c\/p\u003e\n\u003cp data-start=\"3474\" data-end=\"3546\"\u003eOfficial Article: \u003ca data-start=\"3492\" data-end=\"3546\" rel=\"noopener\" class=\"decorated-link cursor-pointer\"\u003ehttps:\/\/academic.oup.com\/jcem\/article\/91\/3\/799\/2843374\u003c\/a\u003e\u003c\/p\u003e\n\u003cp data-start=\"3548\" data-end=\"3597\"\u003ePubMed: \u003ca data-start=\"3556\" data-end=\"3597\" rel=\"noopener\" class=\"decorated-link\" href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/16352683\/\"\u003ehttps:\/\/pubmed.ncbi.nlm.nih.gov\/16352683\/\u003c\/a\u003e\u003c\/p\u003e\n\u003chr data-start=\"3599\" data-end=\"3602\"\u003e\n\u003ch3 data-section-id=\"fm0ars\" data-start=\"3604\" data-end=\"3658\"\u003eGrowth Hormone-Releasing Factor Analogue Structure\u003c\/h3\u003e\n\u003cp data-start=\"3660\" data-end=\"3829\"\u003e\u003cstrong data-start=\"3660\" data-end=\"3690\"\u003eCoy, D. H., et al. (1987).\u003c\/strong\u003e \u003cem data-start=\"3691\" data-end=\"3815\"\u003eDifferential Effects of N-Terminal Modifications on the Biological Potencies of Growth Hormone-Releasing Factor Analogues.\u003c\/em\u003e \u003cstrong data-start=\"3816\" data-end=\"3828\"\u003ePeptides\u003c\/strong\u003e.\u003c\/p\u003e\n\u003cp data-start=\"3831\" data-end=\"3879\"\u003ePubMed: \u003ca data-start=\"3839\" data-end=\"3879\" rel=\"noopener\" class=\"decorated-link\" href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/3100799\/\"\u003ehttps:\/\/pubmed.ncbi.nlm.nih.gov\/3100799\/\u003c\/a\u003e\u003c\/p\u003e\n\u003chr data-start=\"3881\" data-end=\"3884\"\u003e\n\u003ch3 data-section-id=\"xn1p51\" data-start=\"3886\" data-end=\"3954\"\u003eGrowth Hormone-Releasing Factor Structure-Activity Relationships\u003c\/h3\u003e\n\u003cp data-start=\"3956\" data-end=\"4146\"\u003e\u003cstrong data-start=\"3956\" data-end=\"4002\"\u003eRobberecht, P., Coy, D. H., et al. (1985).\u003c\/strong\u003e \u003cem data-start=\"4003\" data-end=\"4127\"\u003eStructural Requirements for the Activation of Rat Anterior Pituitary Adenylate Cyclase by Growth Hormone-Releasing Factor.\u003c\/em\u003e \u003cstrong data-start=\"4128\" data-end=\"4145\"\u003eEndocrinology\u003c\/strong\u003e.\u003c\/p\u003e\n\u003cp data-start=\"4148\" data-end=\"4196\"\u003ePubMed: \u003ca data-start=\"4156\" data-end=\"4196\" rel=\"noopener\" class=\"decorated-link\" href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/2994998\/\"\u003ehttps:\/\/pubmed.ncbi.nlm.nih.gov\/2994998\/\u003c\/a\u003e\u003c\/p\u003e\n\u003chr data-start=\"4198\" data-end=\"4201\"\u003e\n\u003ch3 data-section-id=\"1e85m2q\" data-start=\"4203\" data-end=\"4232\"\u003eGrowth Hormone Physiology\u003c\/h3\u003e\n\u003cp data-start=\"4234\" data-end=\"4403\"\u003e\u003cstrong data-start=\"4234\" data-end=\"4261\"\u003eVeldhuis, J. D., et al.\u003c\/strong\u003e \u003cem data-start=\"4262\" data-end=\"4351\"\u003eStudies investigating pulsatile growth hormone secretion and neuroendocrine regulation.\u003c\/em\u003e \u003cstrong data-start=\"4352\" data-end=\"4403\"\u003eJournal of Clinical Endocrinology \u0026amp; Metabolism.\u003c\/strong\u003e\u003c\/p\u003e\n\u003chr data-start=\"4405\" data-end=\"4408\"\u003e\n\u003ch2 data-section-id=\"2pxu0u\" data-start=\"4410\" data-end=\"4443\"\u003eTechnical Documentation Notice\u003c\/h2\u003e\n\u003cp data-start=\"4445\" data-end=\"4890\"\u003eThis material is supplied exclusively for laboratory research purposes. For validated technical information regarding growth hormone-releasing hormone analogues, pituitary GHRH receptor pharmacology, endocrine signalling pathways, and growth hormone physiology, researchers are encouraged to consult peer-reviewed scientific literature and established biomedical databases, including PubMed\/NCBI, using the primary publications referenced above.\u003c\/p\u003e\n\u003cp data-start=\"4892\" data-end=\"5015\" data-is-last-node=\"\" data-is-only-node=\"\"\u003e\u003cstrong data-start=\"4892\" data-end=\"5015\" data-is-last-node=\"\"\u003eFor Research Use Only (RUO). Not for human consumption, veterinary use, clinical application, or diagnostic procedures.\u003c\/strong\u003e\u003c\/p\u003e","brand":"Seren Labs | UK | Research Peptides","offers":[{"title":"Default Title","offer_id":57622112436606,"sku":null,"price":19.0,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1009\/0263\/3854\/files\/ChatGPTImageJun28_2026_08_59_12PM.png?v=1783427992","url":"https:\/\/www.seren-labs.com\/products\/cjc-1295-no-dac","provider":"Seren Labs | UK | Research Peptides","version":"1.0","type":"link"}