{"title":"Body Composition Research","description":"","products":[{"product_id":"mots-c","title":"MOTS-c","description":"\u003cp class=\"_0f3Qo bceXv\" id=\"xmvbk24580\" data-pm-slice=\"0 0 []\"\u003e\u003cstrong\u003e\u003cem\u003eThis product is synthesized and distributed exclusively for in vitro laboratory experimentation and in vivo animal research models. It is strictly NOT intended for human consumption, diagnostic procedures, or therapeutic use. All handling, reconstitution, and deployment must be conducted by qualified laboratory professionals using proper personal protective equipment.\u003c\/em\u003e\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp class=\"_0f3Qo bceXv\" id=\"b9eo827513\"\u003e\u003c\/p\u003e\n\u003cp class=\"_0f3Qo bceXv\" id=\"osky54744\"\u003e\u003cstrong\u003eOverview\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp class=\"_0f3Qo bceXv\" id=\"isagw4746\"\u003eMOTS-c (Mitochondrial ORF of the 12S rRNA Type-C) is a naturally occurring, 16-amino acid structural peptide encoded within the mitochondrial genome rather than the nuclear DNA. This signalling molecule serves as a critical model for investigating mitochondrial-nuclear communication. Under induced metabolic stress in laboratory environments, the peptide translocates directly to the cell nucleus to regulate adaptive nuclear gene expression and sustain homeostatic balance.\u003c\/p\u003e\n\u003cp class=\"_0f3Qo bceXv\" id=\"eqinm8391\"\u003e\u003c\/p\u003e\n\u003cp class=\"_0f3Qo bceXv\" id=\"2n8k54748\"\u003e\u003cstrong\u003eKey Research Applications\u003c\/strong\u003e\u003c\/p\u003e\n\u003cdiv\u003e\n\u003cul class=\"mC7BJ\" id=\"uwvoy4750\" offset=\"0\"\u003e\n\u003cli class=\"fU8f2\" dir=\"auto\" id=\"hbqwn4751\"\u003e\n\u003cp class=\"_0f3Qo bceXv\" id=\"iy51p4752\"\u003e\u003cstrong\u003eMetabolic Signaling Pathways:\u003c\/strong\u003e Extensively utilized to explore cell-autonomous metabolic homeostasis, specifically focusing on its interaction with the folate-purine pathway and downstream activation of AMP-activated protein kinase (AMPK).\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli class=\"fU8f2\" dir=\"auto\" id=\"xt8t54755\"\u003e\n\u003cp class=\"_0f3Qo bceXv\" id=\"ueg2k4756\"\u003e\u003cstrong\u003eSkeletal Muscle Bioenergetics:\u003c\/strong\u003e Serves as a key analog in in vitro and in vivo animal studies examining cellular glucose uptake, fatty acid oxidation efficiency, and localized ATP kinetics.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli class=\"fU8f2\" dir=\"auto\" id=\"4i9oh4759\"\u003e\n\u003cp class=\"_0f3Qo bceXv\" id=\"at9y64760\"\u003e\u003cstrong\u003eCellular Aging and Atrophy Modeling:\u003c\/strong\u003e Studied in longevity paradigms to evaluate the impacts of age-dependent mitochondrial decline, age-associated insulin resistance, and myostatin-mediated muscle wasting signaling.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli class=\"fU8f2\" dir=\"auto\" id=\"u5sjp4763\"\u003e\n\u003cp class=\"_0f3Qo bceXv\" id=\"qlq7o4764\"\u003e\u003cstrong\u003eStress Adaptation Genetics:\u003c\/strong\u003e Used to investigate cellular resilience profiles under carbohydrate or lipid overload conditions, signaling directly via antioxidant response elements (ARE) within the nucleus.\u003c\/p\u003e\n\u003cp class=\"_0f3Qo bceXv\" id=\"pufl08154\"\u003e\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003c\/div\u003e\n\u003cp class=\"_0f3Qo bceXv\" id=\"i2wqv4767\"\u003e\u003cstrong\u003eTechnical Specifications\u003c\/strong\u003e\u003c\/p\u003e\n\u003cdiv\u003e\n\u003cul class=\"mC7BJ\" id=\"6fgvk4769\" offset=\"0\"\u003e\n\u003cli class=\"fU8f2\" dir=\"auto\" id=\"4oz8s4770\"\u003e\n\u003cp class=\"_0f3Qo bceXv\" id=\"iwogh4771\"\u003e\u003cstrong\u003eSequence:\u003c\/strong\u003e Met-Arg-Trp-Gln-Glu-Met-Gly-Tyr-Ile-Phe-Tyr-Pro-Arg-Lys-Leu-Arg (MRWQEMGYIFYPRKLR)\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli class=\"fU8f2\" dir=\"auto\" id=\"cw1pr4774\"\u003e\n\u003cp class=\"_0f3Qo bceXv\" id=\"5jd7e4775\"\u003e\u003cstrong\u003eMolecular Formula:\u003c\/strong\u003e C₉₄H₁₃₉N₂₅O₃₀\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli class=\"fU8f2\" dir=\"auto\" id=\"6h9kj4778\"\u003e\n\u003cp class=\"_0f3Qo bceXv\" id=\"p15qm4779\"\u003e\u003cstrong\u003eMolecular Weight:\u003c\/strong\u003e ~2174.6 Da\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli class=\"fU8f2\" dir=\"auto\" id=\"6pzjb4782\"\u003e\n\u003cp class=\"_0f3Qo bceXv\" id=\"47uvg4783\"\u003e\u003cstrong\u003eClassification:\u003c\/strong\u003e Mitochondrial-Derived Peptide (MDP)\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003c\/div\u003e\n\u003cp class=\"_0f3Qo bceXv\" id=\"r68037916\"\u003e\u003c\/p\u003e\n\u003cp class=\"_0f3Qo bceXv\" id=\"axyd64790\"\u003e\u003cstrong\u003eScientific References \u0026amp; Literature Citations\u003c\/strong\u003e\u003c\/p\u003e\n\u003cdiv\u003e\n\u003cul class=\"mC7BJ\" id=\"b5gf24792\" offset=\"0\"\u003e\n\u003cli class=\"fU8f2\" dir=\"auto\" id=\"t470j4793\"\u003e\n\u003cp class=\"_0f3Qo bceXv\" id=\"kv5iv4794\"\u003e\u003cstrong\u003eDiscovery \u0026amp; Structural Characterization:\u003c\/strong\u003e\u003c\/p\u003e\n\u003cdiv\u003e\n\u003cul class=\"mC7BJ\" id=\"49gcj4796\" offset=\"0\"\u003e\n\u003cli class=\"fU8f2\" dir=\"auto\" id=\"c0y684797\"\u003e\n\u003cp class=\"_0f3Qo bceXv\" id=\"d6izk4798\"\u003eLee, C., et al. (2015). \"The mitochondrial-derived peptide MOTS-c promotes metabolic homeostasis and reduces obesity and insulin resistance.\" \u003cem\u003eCell Metabolism\u003c\/em\u003e, 21(3), 443-454.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli class=\"fU8f2\" dir=\"auto\" id=\"wqnd54802\"\u003e\n\u003cp class=\"_0f3Qo bceXv\" id=\"sua0h4803\"\u003eKim, K. H., et al. (2018). \"Mitochondria-derived peptides as novel regulators of metabolism.\" \u003cem\u003eJournal of Molecular Medicine\u003c\/em\u003e, 96(2), 110-117.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003c\/div\u003e\n\u003c\/li\u003e\n\u003cli class=\"fU8f2\" dir=\"auto\" id=\"8x9c34807\"\u003e\n\u003cp class=\"_0f3Qo bceXv\" id=\"mfyd44808\"\u003e\u003cstrong\u003eCellular Pathways \u0026amp; AMPK Activation:\u003c\/strong\u003e\u003c\/p\u003e\n\u003cdiv\u003e\n\u003cul class=\"mC7BJ\" id=\"vop5i4810\" offset=\"0\"\u003e\n\u003cli class=\"fU8f2\" dir=\"auto\" id=\"swakz4811\"\u003e\n\u003cp class=\"_0f3Qo bceXv\" id=\"9aocf4812\"\u003eReynolds, J. C., et al. (2021). \"MOTS-c is an exercise-induced mitochondrial-derived peptide that modulates aging and metabolism.\" \u003cem\u003eNature Communications\u003c\/em\u003e, 12(1), 566.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli class=\"fU8f2\" dir=\"auto\" id=\"wpa0o4816\"\u003e\n\u003cp class=\"_0f3Qo bceXv\" id=\"azxfc4817\"\u003eZhai, D., et al. (2023). \"MOTS-c: A promising mitochondrial-derived peptide for the treatment of age-related metabolic disorders.\" \u003cem\u003eJournal of Translational Medicine\u003c\/em\u003e, 21(1), 52.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003c\/div\u003e\n\u003c\/li\u003e\n\u003cli class=\"fU8f2\" dir=\"auto\" id=\"r0vq14821\"\u003e\n\u003cp class=\"_0f3Qo bceXv\" id=\"b7gxs4822\"\u003e\u003cstrong\u003eMuscle Bioenergetics \u0026amp; Atrophy Signaling:\u003c\/strong\u003e\u003c\/p\u003e\n\u003cdiv\u003e\n\u003cul class=\"mC7BJ\" id=\"m7slf4824\" offset=\"0\"\u003e\n\u003cli class=\"fU8f2\" dir=\"auto\" id=\"0n2je4825\"\u003e\n\u003cp class=\"_0f3Qo bceXv\" id=\"eb90f4826\"\u003eLeciejewska, N., et al. (2025). \"MOTS-c impact on muscle cell differentiation and metabolism across fiber types.\" \u003cem\u003eCellular Physiology and Biochemistry\u003c\/em\u003e, 69(1), 12-25.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli class=\"fU8f2\" dir=\"auto\" id=\"sx6n64830\"\u003e\n\u003cp class=\"_0f3Qo bceXv\" id=\"2d85p4831\"\u003eKumagai, H., et al. (2021). \"MOTS-c reduces myostatin and muscle atrophy signaling through the inhibition of FOXO1 transcription factors.\" \u003cem\u003eFASEB Journal\u003c\/em\u003e, 35(3), e21350.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003c\/div\u003e\n\u003c\/li\u003e\n\u003cli class=\"fU8f2\" dir=\"auto\" id=\"p054m4835\"\u003e\n\u003cp class=\"_0f3Qo bceXv\" id=\"z57gz4836\"\u003eTezze, C., et al. (2026). \"MOTS-c improves intrinsic muscle mitochondrial bioenergetic health and efficiency in a PGC-1α\/AMPK-dependent manner.\" \u003cem\u003eFree Radical Biology and Medicine\u003c\/em\u003e, 246, 682-696.\u003c\/p\u003e\n\u003cp class=\"_0f3Qo bceXv\" id=\"3nij16004\"\u003e\u003c\/p\u003e\n\u003cp class=\"_0f3Qo bceXv\" id=\"hemk06821\"\u003e\u003cstrong\u003eTechnical Documentation Notice:\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp class=\"_0f3Qo bceXv\" id=\"scual7079\"\u003e\u003c\/p\u003e\n\u003cp class=\"_0f3Qo bceXv\" id=\"uss9c7284\"\u003eThis material is offered for laboratory research use only. For verified technical documentation regarding mitochondrial open reading frames (sORFs) and systemic metabolic homeostasis, please cross-reference standard medical indexing networks (e.g., PubMed\/NCBI) using the foundational research publications listed above.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003c\/div\u003e\n\u003cp class=\"_0f3Qo bceXv\" id=\"6iuff4844\"\u003e\u003c\/p\u003e","brand":"My Store","offers":[{"title":"Default Title","offer_id":57614402814334,"sku":null,"price":17.0,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1009\/0263\/3854\/files\/ChatGPTImageJun26_2026_06_58_53PM_6cdee5ab-6fb4-4c8a-832a-bc6afcfd45ef.png?v=1782496841"}],"url":"https:\/\/www.seren-labs.com\/collections\/body-composition-research.oembed","provider":"Seren Labs | UK | Research Peptides","version":"1.0","type":"link"}